Yes, it's possible to use Adobe LiveCycle or newer versions of Adobe Acrobat Professional to enable special features in PDF documents that provide advanced functionality (usually only available in Adobe Acrobat) when opened in Adobe Reader.

These enabled PDF files allow people with Adobe Reader to save the file to a local hard drive, fill out forms, add comments and other markups, share it with others, and submit a completed document electronically. In addition, Adobe PDF files can be enabled to allow people to digitally sign, certify, and authenticate a document.

Unfortunately it's only possible to enable these extended features in Adobe Reader using Adobe's software. There isn't any third parties that can provide similar solutions.